Pyrazoles useful in the treatment of inflammation

Details Pyrazoles useful in the treatment of inflammation Pyrazoles useful in the treatment of inflammation

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61K 31/424 (2006.01) A61P 29/00 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2684701

There is provided compounds of formula (I), wherein R1, R2, A1, A2, A3 and A4 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

L'invention porte sur des composés de formule (I), dans laquelle R1, R2, A1, A2, A3 et A4 ont des significations données dans la description, et sur des sels pharmaceutiquement acceptables de ceux-ci. Ces composés sont utiles dans le traitement de maladies dans lesquelles l'inhibition de l'activité d'une lipoxygénase (par exemple, la 15-lipoxygénase) est souhaitée et/ou requise, et, en particulier, dans le traitement de l'inflammation.

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