Pyrazolidine derivative, radical scavenger, brain-infarction...

Details Pyrazolidine derivative, radical scavenger, brain-infarction... Pyrazolidine derivative, radical scavenger, brain-infarction...

C - Chemistry, Metallurgy

07

D

C07D 231/04 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2173305

A pyrazolidine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: Image formula 1 wherein A represents a group expressed by -CH2-, -CO-, -CS-, -CH2CO-, or -CH=CH-CO-; B represents a group expressed by -O- or -NH-; n is an integer of 1 or 2; R represents an alkenyl group; and R1 and R2 represent a lower alkyl or benzyl group. The pyrazolidine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

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