C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/08 (2006.01) A61K 31/4152 (2006.01) A61P 9/00 (2006.01) A61P 15/00 (2006.01)
Patent
CA 2463102
The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.
L'invention concerne des composés de pyrazolidinone substitués et des méthodes de traitement et des compositions pharmaceutiques qui utilisent ou qui renferment un ou plusieurs de ces composés. Les composés de l'invention peuvent être utilisés dans diverses thérapies, y compris pour le traitement ou la prévention de l'accouchement prématuré, de la dysménorrhée, de l'asthme, de l'hypertension artérielle, de l'infertilité ou des troubles de la fertilité, de la thrombose, de la prééclampsie ou de l'éclampsie, des troubles éosinophiliques, de la dysfonction sexuelle, de l'ostéoporose et d'autres maladies ou troubles induisant une détérioration des os, et d'autres maladies et troubles liés aux récepteurs EP2 et/ou EP4 aux prostaglandines.
Araldi Gian Luca
Liao Yihua
Reddy Adulla P.
Zhao Zhong
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Merck Serono Sa
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