Pyrazolo [1,5-a] pyrimidine compounds

Details Pyrazolo [1,5-a] pyrimidine compounds Pyrazolo [1,5-a] pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2710454

This invention relates generally to pyrazolo [1,5-a] pyrimidine-based modulators of Liver X receptors (LXRs) having formula (I) and related methods: Formula (I)wherein R2 is C6-C10 aryl or heteroaryl including 5-10 atoms, each of which is: (i) substituted with 1 R6, and (ii) optionally substituted with from 1-5 Re; and R1, R3, R4, R5, R6 and Re are defined herein.

La présente invention concerne de manière générale des modulateurs des récepteurs X du foie (LXR) à base de pyrazolo-[1,5-a]-pyrimidine de formule (I) et des procédés en relation avec ceux-ci : Formule (I) R2 représentant un aryle ou hétéroaryle en C6 à C10 comprenant 5 à 10 atomes, chacun d'entre eux étant : (i) substitué par un R6, et (ii) éventuellement substitué par de 1 à 5 Re; et R1, R3, R4, R5, R6 et Re étant tels que définis ici.

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