Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) A61P 25/30 (2006.01)

Patent

CA 2623982

The present invention relates to a novel pyrazolo[1,5-a]pyrimidine compound of the formula [I]: (see formula I) wherein Ring A is a substituted pyrazole ring fused to the adjacent pyrimidine ring having the following formula (A), (B) or (C), (see formula A) (see formula B) ( see formula C) or a pharmaceutically acceptable salt thereof. The compounds of the present invention have potent central cannabinoid receptor antagonizing activity and is useful as a medicine.

L'invention concerne un composé pyrazolo[1,5-a]pyrimidine représenté par la formule [I], dans laquelle le noyau A représente un noyau pyrazole substitué fusionné au noyau pyrimidine adjacent représenté par la formule suivante (A), (B) ou (C), ou un sel pharmaceutiquement acceptable de ce dernier.

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