C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 21/04 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2516824
The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth. H,N,R3
La présente invention a trait à des dérives de pyrazolo[1,5-a]pyrimidine de formule (I) et leurs sels pharmaceutiquement acceptables présentant une excellente activité inhibitrice de la kinase. L'invention a également trait à des médicaments comportant les composés comme principes actifs utiles en tant qu'agents thérapeutiques ou prophylactiques pour un trouble lié à la protéine kinase dans lequel la kinase est impliquée, tel que la maladie inflammatoire, la maladie auto-immune, le trouble destructeur d'os, le cancer et/ou la croissance tumorale.
Fujino Aiko
Harris Clifford John
Imai Minoru
Kataoka Kenichiro
Kosugi Tomomi
Borden Ladner Gervais Llp
Teijin Pharma Limited
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