Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as...

Details Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as... Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2584567

CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in mammals. The CRF receptor antagonists of this invention have the following structure: (I); and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2a, R2b, Y, Het, n, o, R6, Ar and R7 are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

L'invention concerne des antagonistes vis-à-vis du récepteur CRF pouvant être utiles dans le traitement de divers troubles, y compris le traitement des troubles qui se manifestent par une hypersécrétion du CRF chez les mammifères. Les antagonistes ont la structure ci-après (I). Les antagonistes s'entendent aussi des sels, esters, solvates, stéréoisomères et promédicaments pharmaceutiquement acceptables, et pour les besoins de la formule décrite, R1, R2a, R2b, Y, Het, n, o, R6, Ar et R7 sont tels que définis dans la description. On décrit aussi des compositions qui renferment un antagoniste vis-à-vis du récepteur CRF combinées à un vecteur pharmaceutiquement acceptable, et des procédés d'utilisation correspondants.

Affiliated with

Also associated with

Rating

Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1564952