Pyrazolo[3,4-b]pyridin-6-ones as gsk-3 inhibitors

Details Pyrazolo[3,4-b]pyridin-6-ones as gsk-3 inhibitors Pyrazolo[3,4-b]pyridin-6-ones as gsk-3 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2525245

The present invention provides compounds of formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2 and R3 are as defined herein; pharmaceutical formulations thereof; and use thereof in the treatment of, inter alia, conditions, diseases, and symptoms such as bipolar disorder, diabetes, dementia, Alzheimer's Disease, stroke, schizophrenia, depression, hair loss, and cancer.

La présente invention concerne des composés de formule (I), leurs stéréoisomères et promédicaments, ainsi que les sels pharmaceutiquement acceptables des composés, stéréoisomères et promédicaments. Dans cette formule, R?1¿, R?2¿ et R?3¿ sont tels que définis dans la description. L'invention concerne également des formulations pharmaceutiques de ces composés et leur utilisation pour traiter, entre autres, des pathologies, des maladies et des symptômes, par exemple le trouble bipolaire, le diabète, la démence, la maladie d'Alzheimer, les accidents cérébraux vasculaires, la schizophrénie, la dépression, la chute des cheveux et le cancer.

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