Pyrazolo[3,4-b]pyridine compounds, and their use as pde4...

Details Pyrazolo[3,4-b]pyridine compounds, and their use as pde4... Pyrazolo[3,4-b]pyridine compounds, and their use as pde4...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2659539

The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (x): and wherein: Q1 is NH or NMe, in which case Q2 is -C(O)-, -S(O)2-, -C(O)NH- or -C(O)NMe-; or Q1 is a bond or -O-, in which case Q2 is a bond; or Q1 is -C(O)-, in which case Q2 is NH or NMe; or Q1 is -S(O)2-, in which case Q2 is NH, NMe or a bond; and L is (CH2)n wherein n is 4 to 13; or L is -(CH2)m 1-O-(CH2)m 2-. The invention also provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, or rhinitis (e.g. allergic and/or non-allergic rhinitis).

L'invention concerne un composé représenté par la formule (I) ou un sel de celui-ci. Dans ladite formule (I), Ar est représenté par la sous-formule (x), dans laquelle: Q1 représente NH ou NMe, auquel cas Q2 représente -C(O)-, -S(O)2-, -C(O)NH- ou -C(O)NMe-; ou Q1 représente une liaison ou -O-, auquel cas Q2 représente une liaison; ou Q1représente -C(O)-, auquel cas Q2 représente NH ou NMe; ou Q1 représente -S(O)2-, auquel cas Q2 représente NH, NMe ou une liaison; et L représente (CH2)n, n étant compris entre 4 et 13; ou L représente -(CH2)m 1-O-(CH2)m 2-. L'invention concerne également l'utilisation des composés en tant qu'inhibiteurs de phosphodiestérase de type IV (PDE4) et/ou pour le traitement et/ou la prophylaxie de maladies inflammatoires et/ou allergiques telles que la bronchopneumopathie chronique obstructive (BPCO), l'asthme, ou la rhinite (par ex., rhinite allergique et/ou non allergique).

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