Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation...

Details Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation... Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2700327

A pyrazolo [5,1-c] [1,2,4] triazine compound of Formula (A): and pharmaceutically acceptable sats thereof. The multiply-substituted pyrazolo[5,1-c][1,2,4]triazine com-pounds of the invention selectively inhibit B-Raf kinase activity and are useful for treating disorders mediated by B-Raf kinase.

L'invention concerne un composé de pyrazolo[5,1-c]-[1,2,4]-triazine de formule (A) : et des sels pharmaceutiquement acceptables de celui-ci. Les composés de pyrazolo[5,1-c]-[1,2,4]-triazine polysubstitués de la présente invention inhibent de manière sélective l'activité de la B-Raf kinase et sont utiles pour traiter des troubles provoqués par la B-Raf kinase.

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