Pyrazolo-pyridines as tyrosine kinase inhibitors

Details Pyrazolo-pyridines as tyrosine kinase inhibitors Pyrazolo-pyridines as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2698753

Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

L'invention concerne des composés de formules Ia et Ib, ainsi que leurs stéréisomères, leurs isomères géométriques, leurs tautomères, leurs solvates, leurs métabolites et leurs sels pharmaceutiquement acceptables, qui sont utiles pour l'inhibition des récepteurs tyrosine kinases et pour le traitement des troubles induits par ces récepteurs. L'invention concerne également des procédés d'utilisation des composés de formules Ia et Ib, ainsi que leurs stéréoisomères, leurs isomères géométriques, leurs tautomères, leurs solvates et leurs sels pharmaceutiquement acceptables, pour le diagnostic in vitro, in situ et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammifères ou d'états pathologiques associés.

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