Pyrazolo pyrimidines useful as aurora kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 487/16 (2006.01)

Patent

CA 2615946

The present invention provides compounds having the formula: (I) wherein A-B together represent one of the following structures: (II) or (III) wherein one of ---- is a double bond, as valency permits; and R2, R4, X 1A, X2A, X1B, X2B, L1, L2, Y an Z are as defined in classes and subclasess herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.

La présente invention concerne des composés répondant à la formule (I) dans laquelle le groupement A-B représente la structure (II) ou la structure (III) dans lesquelles l'un des traits formés de tirets est une double liaison, selon ce que permet la valence; et R2, R4, X1A, X2A, X1B, X2B, L1, L2, Y et Z sont tels que définis dans les classes et sous-classes présentées dans l'invention, et des compositions pharmaceutiques desdits composés, telles que décrites en général et dans les sous-classes présentées dans l'invention, lesquels composés sont utiles comme inhibiteurs de protéines kinases (par exemple de la kinase Aurora) et sont donc utiles, par exemple, pour le traitement de maladies médiées par la kinase Aurora.

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