Pyrazolobenzodiazepines as cdk2 inhibitors

Details Pyrazolobenzodiazepines as cdk2 inhibitors Pyrazolobenzodiazepines as cdk2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/55 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01) C07D 243/22 (2006.01)

Patent

CA 2367704

Novel pyrazolobenzodiazepines having formula (I) and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein inhibit cyclin-dependent kinases (CDKs), in particular CDK2, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular breast, colon, lung and prostate tumors.

Les nouvelles pyrazolobenzodiazépines de formule (I) et leurs sels acceptables au plan pharmaceutique, formule (I) dans laquelle, R<1>, R<2>, R<3> et R<4> sont tels que définis, inhibent les kinases dépendantes des cyclines (CDK), notamment CDK2, et sont des agents anti-prolifératifs utiles dans le traitement ou la lutte contre la prolifération cellulaire anormale, notamment des tumeurs du sein, du colon, des poumons et de la prostate.

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