Pyrazolopyridine-1,4-diamines and analogs thereof

Details Pyrazolopyridine-1,4-diamines and analogs thereof Pyrazolopyridine-1,4-diamines and analogs thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2602683

Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4- c]pyridine-1,4-diamines, pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9- tetrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, and pyrazolo[3,4- c]naphthyridine-1,4-diamines, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

L'invention concerne des pyrazolopyridine-1,4-diamines et des analogues associés, par exemple, des pyrazolo[3,4-c]pyridine-1,4-diamines, des pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tétrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, et des pyrazolo[3,4-c]naphthyridine-1,4-diamines, des compositions pharmaceutiques renfermant lesdits composés, des intermédiaires, des méthodes d'élaboration desdits composés et des méthodes d'utilisation de ces composés en tant qu'immunomodulateurs pour l'induction de la biosynthèse de la cytokine chez des animaux et dans le traitement de maladies, y compris, des maladies virales et néoplasiques.

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