Pyrazolopyridine adenosine antagonists

Details Pyrazolopyridine adenosine antagonists Pyrazolopyridine adenosine antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2180253

The present invention relates to a novel pyrazolopyridine compound of formula (I) wherein R1 is aryl, and R2 is cyclo(lower)alkyl which may have one or more suitable substitutent(s), etc; and a pharmaceutically acceptable salt thereof, which is useful as a medicament. The pyrazolopyridine compound or a pharmaceutically acceptable salt thereof is an adenosine antagonist (especially, A1 receptor antagonist) and possesses various pharmacological actions.

L'invention concerne un nouveau composé pyrazolopyridine de formule (I), dans laquelle R?1¿ désigne aryle, et R?2¿ désigne cycloalkyle (inférieur) qui peut avoir un ou plusieurs substituants appropriés, etc.; et un de ses sels acceptable sur le plan pharmaceutique, qui s'utilise comme médicament. Un tel composé pyrazolopyridine ou son sel acceptable sur le plan pharmaceutique est un antagoniste de l'adénosine (notamment un antagoniste du récepteur A¿1?) et présente différents effets pharmacologiques.

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