C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4162 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 25/36 (2006.01)
Patent
CA 2611296
The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (.beta.ARK-1 ), compositions containing such-compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.
L'invention concerne des dérivés de pyrazolopyridine 6-amido substitués de formule (I) utiles en tant qu'inhibiteurs de la kinase 1 du récepteur bêta-adrénergique (.beta.ARK-1), des compositions contenant lesdits composés et leur utilisation pour le traitement et la prévention de l'insuffisance cardiaque chronique, de l'hypertension, de l'ischémie myocardique et d'infections par le virus de l'hépatite C (HCV), ainsi que pour la prévention de la toxicomanie opiacée.
Bjergarde Kirsten
Huber Jochen
Patek Marcel
Pirard Bernard
Ritter Kurt
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis
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