C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/16 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 495/22 (2006.01) C07D 498/22 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2663965
[PROBLEMS] To provide a novel compound capable of inhibiting the activity of HSP90, particularly a novel compound capable of inhibiting the chaperon protein function of HSP90 and having an anti-tumor activity. [MEANS FOR SOLVING PROBLEMS] A pyrazolopyrimidine compound represented by the formula (1) having various substituents, which is capable of inhibiting the ATPase activity of HSP90 and has an anti-tumor activity; an HSP90 inhibitor comprising the compound represented by the formula (1); a pharmaceutical agent comprising the compound represented by the formula (1); an anti-cancer agent comprising the compound represented by the formula (1); a pharmaceutical composition comprising the compound represented by the formula (1); a method for the treatment of cancer by using the compound represented by the formula (1); and others. (1)
Cette invention propose un nouveau composé capable d'inhiber l'activité de HSP90, en particulier un nouveau composé capable d'inhiber la fonction de protéine chaperon de HSP90 et ayant une activité anti-tumeur. L'invention concerne donc un composé de pyrazolopyrimidine représenté par la formule (1) ayant divers substituants, qui est capable d'inhiber l'activité ATPase HSP90 et possède une activé anti-tumeur ; un inhibiteur de HSP90 comportant le composé représenté par la formule (1) ; un agent pharmaceutique comportant le composé représenté par la formule (1) ; un agent anti-cancer comportant le composé représenté par la formule (1) ; une composition pharmaceutique comportant le composé représenté par la formule (1) ; un procédé pour le traitement du cancer par l'utilisation du composé représenté par la formule (1) ; et autres. (1)
Ikeda Masahiro
Nagata Chikahiro
Ohsuki Satoru
Shibata Yoshihiro
Shimada Takashi
Daiichi Sankyo Company Limited
Marks & Clerk
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