C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/14 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2601717
A pyrazolopyrimidine derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof exhibits excellent MAPKAP-K2 inhibitory activity. A pharmaceutical agent comprising the compound as the active ingredient is expected to be useful for the treatment of MAPKAP-K2- mediated disorders including inflammatory disorders, autoimmune disease, destructive bone disorders, cancer and/or tumor growth.
L~invention concerne un dérivé de la pyrazolopyrimidine représenté par la formule générale (I) et un sel acceptable du point de vue pharmaceutique de celui-ci qui présentent une excellente activité d~inhibition de la MAPKAP-K2. L~agent pharmaceutique comportant le composé en tant qu~ingrédient actif sera utile pour le traitement des troubles associés à MAPKAP-K2 y compris les troubles inflammatoires, les maladies auto-immunes, les troubles de destruction osseuse, le cancer et/ou la croissance des tumeurs.
Kataoka Kenichiro
Kosugi Tomomi
Makino Hiroaki
Takakuwa Mika
Unoki Gen
Borden Ladner Gervais Llp
Teijin Pharma Limited
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