Pyrazolopyrimidine jak inhibitor compounds and methods

Details Pyrazolopyrimidine jak inhibitor compounds and methods Pyrazolopyrimidine jak inhibitor compounds and methods

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2740792

The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula la and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient. la

L'invention concerne des inhibiteurs de JAK kinase de la formule Ia, des énantiomères, des diastéréomères ou des sels de qualité pharmaceutique de ceux-ci, R1, R2, R7 et Z étant définis par les présentes, une composition pharmaceutique qui comprend un composé de la formule Ia et un vecteur, un adjuvant ou un véhicule de qualité pharmaceutique, et des procédés de traitement ou de réduction de la gravité d'une maladie ou d'un état sensible à l'inhibition d'une activité de JAK kinase chez un patient.

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