C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2711759
Compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
L'invention concerne des composés représentés par la formule I, y compris des stéréo-isomères, des isomères géométriques, des tautomères, des solvates, des métabolites et des sels pharmaceutiquement acceptables de ces composés, qui sont utiles pour inhiber des lipides kinases incluant p110 alpha et d'autres isoformes de PI3K, et pour traiter des troubles tels que le cancer, dans lesquels interviennent les lipides kinases. L'invention concerne aussi des procédés d'utilisation des composés représentés par la formule I pour diagnostiquer, prévenir ou traiter in vitro, in situ et in vivo de tels troubles dans des cellules de mammifère, ou des états pathologiques associés. [Formule I]
Chuckowree Irina
Dotson Jennafer
Folkes Adrian
Heffron Tim
Olivero Alan
F. Hoffmann-La Roche Ag
Genentech Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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