C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2711575
The invention relates to pyrazolopyrimidine derivatives of Formula (I) wherein R1 represents chloro or bromo; A represents (a); (b); (c); (d); or (e), as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
Cette invention concerne des dérivés de pyrazolopyrimidine de formule (I) et leurs sels pharmaceutiquement acceptables. Dans ladite formule, R1 représente chloro ou bromo et A représente (a), (b), (c), (d) ou (e). l'invention concerne également une méthode de préparation de ces composés, qui sont des modulateurs de mGluR5 et sont donc utiles pour la régulation et la prévention de troubles neurologiques aigus et/ou chroniques.
Erdmane Elina
Gravius Andreas
Henrich Markus
Kauss Valerjans
Mueller Sibylle
Merz Pharma Gmbh & Co. Kgaa
Perley-Robertson Hill & Mcdougall Llp
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