Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

Details Pyrazolopyrimidines as cyclin-dependent kinase inhibitors Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) C07D 231/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2497440

In its many embodiments, the present invention provides a novel class of pyrazolo~1,5-a~pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Sous ses nombreuses variantes, l'invention concerne une nouvelle classe de composés de pyrazoloÝ1,5-a¨pyrimidine tenant lieu d'inhibiteurs de kinases dépendantes de la cycline, des procédés d'élaboration correspondants, des compositions pharmaceutiques renfermant un ou plusieurs de ces composés, des procédés relatifs à l'élaboration de formulations pharmaceutiques renfermant un ou plusieurs de ces composés, et des procédés relatifs au traitement, à la prévention, à l'inhibition ou à l'atténuation d'une ou plusieurs maladies associées aux kinases dépendantes de la cycline, qui reposent sur l'utilisation des composés ou des formulations pharmaceutiques en question.

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