Pyrazolopyrimidines as protein kinase inhibitors

Details Pyrazolopyrimidines as protein kinase inhibitors Pyrazolopyrimidines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2624882

In its many embodiments, the present invention provides a novel class of amino- substituted pyrazolo[l , 5 -a] pyrimidine compounds represented by the structural formula (I) as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

L'invention concerne, à travers ses nombreux modes de réalisation, une nouvelle classe de composés pyrazolo[l , 5 -a]pyrimidine avec substitution d'amines selon la formule structurelle (I) servant d'inhibiteurs de protéines kinases et/ou de kinases de point de contrôle, des procédés de préparation desdits composés, des compositions pharmaceutiques comprenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés, et des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs des maladies associées aux protéines kinases ou kinases de point de contrôle utilisant de tels composés ou de telles compositions pharmaceutiques.

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