Pyrazolopyrimidines for decreasing ion flow through a...

Details Pyrazolopyrimidines for decreasing ion flow through a... Pyrazolopyrimidines for decreasing ion flow through a...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) A61P 29/02 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2465326

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

Composés, compositions et procédés utiles dans le traitement de diverses maladies par l'inhibition du flux d'ions de sodium circulant par les canaux sodiques dépendants de la tension. Elle concerne notamment des pyrazolopyrimidines, des compositions et procédés utiles dans le traitement des troubles des systèmes nerveux central et périphérique, en particulier de la douleur et de la douleur chronique, par le blocage des canaux sodiques associés au début ou à la récurrence des états mentionnés ici. Les composés, compositions et procédés de la présente invention sont particulièrement utiles pour le traitement de la douleur neuropathique et inflammatoire par l'inhibition du flux d'ions passant par un canal qui comprend une sous-unité de PN3.

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