C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/41 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2539549
The present invention provides compounds of formula (I): or a pharmaceutically acceptable derivative thereof, wherein A, B, Q, R1, and R2 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds, and methods of utilizing those compositions in the treatment of various disorders.
L'invention concerne des composés de formule (I) ou un de leurs dérivés pharmaceutiquement acceptables, A, B, Q, R?1¿, et R?2¿ étant spécifiés dans la description. Lesdits composés sont des inhibiteurs de la protéine kinase, en particulier des inhibiteurs de la kinase AKT ou PDK1, de protéines kinases de mammifères impliquées dans les troubles poliférants et neurodégénératifs. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés pour préparer les composés, et des procédés d'utilisation desdites compositions dans le traitement de nombreux troubles.
Binch Hayley
Everitt Simon
Mazzei Francesca
Robinson Daniel
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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