C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/06 (2006.01) A61K 31/4162 (2006.01) A61K 31/437 (2006.01) A61P 37/02 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2506524
The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.
La présente invention concerne de nouveaux composés hétérocycliques, des procédés pour les préparer, des compositions les contenant et des procédés et une utilisation pour un traitement clinique de pathologies médicales qui peuvent bénéficier d'une immunomodulation, notamment la polyarthrite rhumatoïde, la sclérose en plaques, le diabète, l'asthme, les transplantations, le lupus érythémateux disséminé et le psoriasis. Cette invention concerne plus particulièrement de nouveaux composés hétérocycliques qui sont des antagonistes de CD80 capables d'inhiber les interactions entre CD80 et CD28.
Brennan Chris James
Coulter Thomas Stephen
Da Graca Thrige Dorthe
Ghiron Chiara
Huxley Philip
Active Biotech Ab
Gowling Lafleur Henderson Llp
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