Pyrazolotriazole derivative

Details Pyrazolotriazole derivative Pyrazolotriazole derivative

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2115996

ABSTRACT This invention relates to a pyrazolotriazole derivative represented by the general formula: Image wherein each symbol means as follows; R1, R3 and R4: one of them represents hydrogen, tetrazolylated biphenylmethyl or lower alkyl, R2: hydrogen, tetrazolylated biphenylmethyl, cycloalkyl or lower alkyl, and R5 and R6: these may be the same or different from each other, and each represents hydrogen, halogen, tetrazolylated biphenylmethyl, formyl, carboxyl, esterified carboxyl, cycloalkyl, lower alkoxy, lower alkoxycarbonyl, or lower alkyl which may be substituted with hydroxyl, formyl or carboxyl, provided that at least one of R1 to R6 is tetrazolylated biphenylmethyl, and the broken lines mean that the pyrazolotriazole ring forms three double bonds, or a pharmaceutically acceptable salt thereof, and to a process for the production thereof, wherein the above compound (I) is useful for treating various diseases caused by the physiological function of angiotensin II. - 216 -

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