C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/20 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) C07D 231/12 (2006.01) C07D 231/14 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 409/04 (2006.01) C07D 453/02 (2006.01) C07D 453/06 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2544519
The invention relates to novel derivatives of general formula (I), wherein A, if present, is an alkyl radical (C1-C6), an alkenyl radical (C3-C6), an alkynyl radical (C3-C6), a cycloalkyl radical (C3-C7), a cycloalkenyl radical (C5-C7), R1 is a NR6R7, azacycloalkyl (C4-C7), azacycloalkenyl (C5-C7) azabicycloalkyl (C5-C9) and azabicycloalkenyl (C5-C9) group; A-R1 is such that nitrogen of R1 et nitrogen 1 of pyrazole are indispensably separated by at lest two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra and NHSO2Ra radical; R4 is an aryl or heteroaryl radical; R5 is a H, halogen, CF3, CHF2, CH2F, linear or branched alkyl (C1-C6) and cycloalkyl (C3-C7) radical, the racemics, enantiomers and diastereoisomers thereof and the mixtures thereof, tautomers thereof and the pharmaceutically acceptable salts thereof.
La présente invention concerne les nouveaux dérivés de formule générale (I) dans laquelle A est, si il est présent, un radical alkyle (C1-C6), un radical alkényle (C3-C6), un radical alkynyle (C3-C6), un radical cycloalkyle (C3-C7), un radical cycloalkényle (C5-C7), R1 est un groupement NR6R7, azacycloalkyle (C4-C7), azacycloalkényle (C5-C7) azabicycloalkyle (C5-C9), azabicycloalkényle (C5-C9) ; A-R1 est tel que l'azote de R1 et l'azote 1 du pyrazole sont obligatoirement séparés par au moins deux atomes de carbone, R3 est un radical H, halogène, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra, NHSO2Ra , R4 est un radical aryle ou hétéroaryle ; R5 est un radical H, halogène, CF3, CHF2, CH2F, alkyle (C1-C6) linéaire ou ramifié, cycloalkyl (C3-C7), leurs racémiques, énantiomères, diastéréoisomères et leurs mélanges, leurs tautomères et leurs sels pharmaceutiquement acceptables.
Bohme Andrees
Bouquerel Jean
Doerflinger Gilles
El-Ahmad Youssef
Evers Michel
Aventis Pharma S.a.
Kirby Eades Gale Baker
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