Pyrazolyl-indole derivatives active as kinase inhibitors,...

Details Pyrazolyl-indole derivatives active as kinase inhibitors,... Pyrazolyl-indole derivatives active as kinase inhibitors,...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4155 (2006.01)

Patent

CA 2531751

Pyrazolyl-indole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

L'invention concerne des dérivés de pyrazolyl-indole représentés par la formule (I) telle que définie dans la description, et des sels de ceux-ci acceptables sur le plan pharmaceutique, un procédé de préparation de ces dérivés et des compositions pharmaceutiques les contenant. Les composés de l'invention peuvent être utiles, en thérapie, dans le traitement de maladies associées à l'activité d'une protéine kinase déréglée, notamment le cancer.

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