Pyridazin-3(2h)-one derivatives and their use as pde4...

Details Pyridazin-3(2h)-one derivatives and their use as pde4... Pyridazin-3(2h)-one derivatives and their use as pde4...

C - Chemistry, Metallurgy

07

D

C07D 237/24 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 11/16 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2570170

The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives of Formula (I) and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention or suppression of pathological conditions, diseases and disorders known to be susceptible of being improved by inhibition of PDE4 such as asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel disease.

L'invention concerne de nouveaux dérivés à usage thérapeutique de pyridazin-3(2H)-one, représentés par la formule (I), et des compositions pharmaceutiques contenant ces dérivés. Ces composés sont des inhibiteurs puissants et sélectifs de la phosphodiestérase 4 (PDE4), et peuvent pas conséquent servir au traitement, à la prévention ou à la suppression d'états pathologiques, de maladies, et de troubles susceptibles de répondre favorablement à l'inhibition de la PDE4, tels que l'asthme, les bronchopneumopathies obstructives chroniques, la polyarthrite rhumatoïde, les dermatites atopiques, le prosiasis ou le syndrome du côlon irritable.

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