Pyridazin-3-one derivatives and medicines containing the same

Details Pyridazin-3-one derivatives and medicines containing the same Pyridazin-3-one derivatives and medicines containing the same

C - Chemistry, Metallurgy

07

D

C07D 237/24 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2364801

Objects of the invention are to provide compounds having excellent activity against interleukin-1.beta. pro-duction and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): (see formula 1) wherein Ar1 represents a substituted or unsubstituted aromatic group, Ar2 represents a phenyl group having a substituent at least at the 4-position thereof, R1 represents a linear or branched alkyl group, an alkyl group having a cyclic structure, a substituted or un-substituted phenyl group or a substituted or un-substituted phenyl(lower alkyl) group, and R2 represents a cyano group, a carboxyl group, a (lower alkoxy)carbonyl group, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted carbamoyl group, or salts thereof; and medicines com-prising them as effective ingredients.

Cette invention se rapporte à des dérivés de pyridazine-3-one, représentés par la formule générale (1) ou à des sels de ces dérivés, qui possèdent un excellent effet inhibiteur de la production d'interleukine-1 beta ; ainsi qu'à des médicaments contenant ces dérivés ou ces sels comme principe actif. Dans ladite formule (1), Ar<1> représente un groupe aromatique éventuellement substitué; Ar<2> représente phényle substitué au moins à la position 4; R<1> représente alkyle linéaire ou ramifié, alkyle ayant une structure cyclique, phényle éventuellement substitué ou phényl-alkyle inférieur éventuellement substitué; et R<2> représente cyano, carboxyle, alcoxycarbonyle inférieur, alkyle inférieur éventuellement substitué ou carbamoyle éventuellement substitué.

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