Pyridazine derivatives and their use as therapeutic agents

Details Pyridazine derivatives and their use as therapeutic agents Pyridazine derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 237/20 (2006.01) A61K 31/501 (2006.01) A61P 3/06 (2006.01) C07D 237/22 (2006.01)

Patent

CA 2597069

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

L'invention concerne des méthodes de traitement d'une maladie ou d'un état induit par les stéaroyl-CoA désaturases (SCD) chez un mammifère, de préférence un humain. Les méthodes selon l'invention consistent à administrer à un mammifère nécessitant un tel traitement un composé de formule (Ia): (Ia), dans laquelle x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 et R9a sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule (I).

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