Pyridazine derivatives and their use as therapeutic agents

Details Pyridazine derivatives and their use as therapeutic agents Pyridazine derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 237/20 (2006.01) A61K 31/501 (2006.01) A61P 3/06 (2006.01) C07D 237/22 (2006.01)

Patent

CA 2533897

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

L'invention concerne des méthodes permettant de traiter une affection ou une maladie induite par des SCD chez un mammifère, de préférence un humain. Ces méthodes consistent à administrer à un mammifère qui le nécessite, un composé représenté par la formule (I): dans cette formule, x, y, W, V, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?6a¿, R?7¿, R?7a¿, R?8¿, R?8a¿, R?9¿ et R?9a¿ sont tels que définis dans le dossier. Cette invention concerne également des compositions pharmaceutiques contenant les composés représentés par la formule (I).

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