C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/501 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2731130
The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperpro-liferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of ac-tion involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.
La présente invention porte d'une manière générale sur de nouveaux composés se rapportant au diagnostic et au traitement de pathologies concernant la voie Hedgehog incluant, mais sans que ceci soit limitatif, la formation tumorale, le cancer, la néoplasie et les troubles hyperprolifératifs non malins. La présente invention concerne de nouveaux composés, de nouvelles compositions, des procédés pour leur utilisation et des procédés pour leur fabrication, de tels composés étant généralement pharmacologiquement utiles en tant quagents dans des thérapies dont le mécanismes d'action met en jeu des procédés d'inhibition de la genèse tumorale, la croissance tumorale et la survie tumorale à l'aide d'agents qui inhibent la voie de signalisation Hedgehog et Smo.
Chen Zhuoliang
He Feng
Lagu Bharat
Miller-Moslin Karen
Peukert Stefan
Fetherstonhaugh & Co.
Novartis Ag
LandOfFree
Pyridazine derivatives as smo inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyridazine derivatives as smo inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridazine derivatives as smo inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1808444