Pyridazinone acetic acids as aldose reductase inhibitors

Details Pyridazinone acetic acids as aldose reductase inhibitors Pyridazinone acetic acids as aldose reductase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/50 (2006.01) C07D 237/14 (2006.01) C07D 237/26 (2006.01) C07D 237/32 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2107104

2107104 9217446 PCTABS00016 Compounds having aldose reductase inhibitory activity of formula (I) wherein X CH2, CH2CH2, -CHCH3, (a); Y=O or S; R1 is an optionally substituted phenyl, benzothiazol-2-yl, benzoxazol-2-yl, benzofuran-2-yl, benzothiophen-2-yl, thiazolopyridin-2-yl, oxazolopyridin-2-yl, 3-phenyl 1,2,4-oxadiazol-5-yl, and 5-phenyl-1,2,4-oxadiazol-3-yl wherein said substituted groups are substituted with one or more and preferably two substituents that are independently selected from fluorine, chlorine, bromine, methyl, and trifluoromethyl; R2 and R3 are independently selected from hydrogen, fluorine, chlorine, bromine, (C1-C4) alkyl, methyl (C1-C4) alkylthio, (C1-C4) alkoxy and trifluoromethyl or R2 and R3 taken together with the carbons to which they are attached form a group W, wherein W is (b) or (c) wherein p is 1 or 2 and U1 and U2 are independently CH2, O or S with the proviso that both U1 and U2 are not O or S; R4 is hydrogen or a prodrug group; or a pharmaceutically acceptable salt thereof.

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