Pyridazinone and triazinone compounds and use thereof as...

Details Pyridazinone and triazinone compounds and use thereof as... Pyridazinone and triazinone compounds and use thereof as...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/53 (2006.01) A61P 25/08 (2006.01) A61P 25/28 (2006.01) C07D 253/06 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2742411

The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. (see formula I) In the formula, A1, A2 and A3 are independent of each other and each represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X1, X2 and X3 are independent of each other and each represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, -NH-, -O-, -NHCO-, -CONH-, -SO0-2-, etc.; R1 and R2 are independent of each other and each represents a hydrogen atom or an optionally substituted C1-6 alkyl group, or R1 and R2 may be bound together such that CR2-ZR1 forms C=C; and R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group etc., or may be bound to any atom in A1 or A3 to form, together with the atom, an optionally substituted C5-8 hydrocarbon ring or an optionally substituted 5- to 8-membered heterocyclic ring.

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