C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/245
C07D 405/00 (2006.01) C07D 405/04 (2006.01) C07D 409/00 (2006.01) C07D 409/04 (2006.01) C07D 413/14 (2006.01)
Patent
CA 1308413
Abstract Pyridazinone derivatives The invention relates to pyridazinone compounds of the general formula I: Image I wherein R1 represents one to four substituents, which may be the same or different and are selected from H, OH, halogen, NO2, unsubstituted or C1-C4 alkyl substituted amino, C1- C4 alkyl, C1-C4 halogen substituted alkyl, O-ALK-NR4R5, C1-C4 alkoxy, whereby two substituents taken together may also represent a methylenedioxy group ; R2 and R3 represent independently H or C1-C4 alkyl; R4 and R5 represent independently H or C1-C4 alkyl, or form together with the nitrogen a 5- or 6- membered ring; X represents S or O; the dotted line represents an optional bond; and their pharmaceutically acceptable salts. The compounds according to the invention have a cardiotonic, blood platelet aggregation inhibiting, systemic vasodilator, pulmonary vasodilator, and bronchodilator activity, and more particularly they show a very potent increase of the force of the muscular contractions of the heart, reduce afterload on the heart, improve pulmonary blood flow, and improve airways ventilation.
605216
Logan Robert Thomas
Mcgarry George
Redpath James
Roy Robert Gibson
Akzo N.v.
Fetherstonhaugh & Co.
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