Pyridazinone derivatives as parp inhibitors

Details Pyridazinone derivatives as parp inhibitors Pyridazinone derivatives as parp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/501 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2704714

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo-or radio sensitizers for cancer treatment.

L'invention porte sur des composés de formule (I) et leurs sels ou tautomères pharmacocompatibles, inhibiteurs de la poly(ADP-ribose) polymérase (PARP), et de ce fait utiles pour le traitement: du cancer, des maladies inflammatoires, des incidents de reperfusion, des états d'ischémie, des attaques, de l'insuffisance rénale, des maladies cardiovasculaires, des maladies vasculaires autres que cardiovasculaires, du diabètes sucré, des maladies neurodégénératives, des infections rétrovirales, des dommages à la rétine, de la sénescence de la peau, des dommages à la peau dus aux UV et aux chimio ou radio sensibilisateurs utilisés lors du traitement du cancer.

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