Pyridazinone derivatives as thyroid hormone receptor agonists

Details Pyridazinone derivatives as thyroid hormone receptor agonists Pyridazinone derivatives as thyroid hormone receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 237/14 (2006.01) A61K 31/501 (2006.01) A61P 5/16 (2006.01) C07D 237/16 (2006.01) C07D 237/18 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2614529

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the sub-stituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholes-terolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, car-diovascular diseases, hypothyroidism, thyroid cancer and other disor-ders and diseases related thereto.

L'invention concerne des composés de la formule (I) et des sels pharmaceutiquement acceptables de ces derniers, les substituants étant tels que mentionnés dans la description. Les composés précités, et les compositions pharmaceutiques les contenant, sont utilisés dans le traitement de maladies telles que l'obésité, l'hyperlipidémie, l'hypercholestérolémie et le diabète et autres affections et maladies liées, et peuvent être utilisés pour d'autres maladies telles que la stéato-hépatite non alcoolique (NASH), l'athérosclérose, les maladies cardiovasculaires, l'hypothyroïdie, le cancer de la thyroïde et autres affections et maladies liées.

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