C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/22 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2138224
Pyridazinone derivatives of formula (I): Image (I) wherein R1 represents a hydrogen atom or a methyl group which may be substituted with an aliphatic cyclic amino group optionally containing a hetero atom in the ring thereof; each of X1 and X2 independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a nitro group or a group shown by - CO-NR2R3 (wherein each of R2 and R3 independently represents an alkyl group having 1 to 6 carbon atoms); Y represents a halogen atom; Z represents an alkoxy group having 1 to 6 carbon atoms; ? represents 0 or an integer of 1 to 3; A represents CH or N; m represents 0 or an integer of 1 or 2; and n represents an integer of 1 to 8, exhibit a platelet aggregation inhibiting activity and are useful for the treatment of circulatory disorders such as cerebral infarction.
Kagawa Takashi
Kanai Kazuo
Motokawa Takuya
Oshita Yoshitami
Yoshida Masanori
Fetherstonhaugh & Co.
Nihon Nohyaku Co. Ltd.
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