Pyridazinone derivatives useful as glucan synthase inhibitors

Details Pyridazinone derivatives useful as glucan synthase inhibitors Pyridazinone derivatives useful as glucan synthase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 237/22 (2006.01) A61K 31/501 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2680583

In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.

L'invention concerne des composés de pyridazinone substitués en tant qu'inhibiteurs de synthase de glucane ; des procédés de préparation de tels composés, des produits pharmaceutiques comprenant un ou plusieurs de ces composés ; des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés seuls ou avec d'autres agents antifongiques ; et des procédés de traitement, de prévention, d'inhibition, ou d'amélioration d'une ou de plusieurs infections fongiques associées à une synthase de glucane utilisant de tels composés ou compositions pharmaceutiques.

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