Pyridazinone hydrochloride compound and method for producing...

C - Chemistry – Metallurgy – 07 – D

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C07D 237/22 (2006.01)

Patent

CA 2326506

The present invention relates to a 3/2-hydrochloride of 4-chloro-5-[3- (4- benzylpiperazin-1- yl)carbonylmethoxy-4- methoxybenzylamino]- 3(2H)- pyridazinone, and also relates to a method for producing the 3/2- hydrochloride of 4-chloro-5-[3- (4-benzylpiperazin-1- yl)carbonylmethoxy-4- methoxybenzylamino]- 3(2H)-pyridazinone which comprises crystallizing in an alcohol type solvent or an alcohol type-ester type mixture solvent in the presence of hydrogen chloride and water.

Cette invention concerne un 3/2-hydrochlorure de 4-chloro-5-[3-(4-benzylpipérazin-1-yl)carbonylméthoxy-4-méthoxybenzylamino]-3(2H)-pyridazinone, ainsi qu'un procédé de production de ce 3/2-hydrochlorure de 4-chloro-5-[3-(4-benzylpipérazin-1-yl)carbonylméthoxy-4-méthoxybenzylamino]-3(2H)-pyridazinone. Ce procédé consiste à effectuer une cristallisation dans un solvant de type alcool ou dans un mélange de solvants de type alcool et de type ester, ceci en présence de chlorure d'hydrogène et d'eau.

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