Pyridazinone ureas as antagonists of .alpha.4 integrins

Details Pyridazinone ureas as antagonists of .alpha.4 integrins Pyridazinone ureas as antagonists of .alpha.4 integrins

C - Chemistry, Metallurgy

07

D

C07D 237/14 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/14 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2555227

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating .alpha.4 integrin mediated disorders. More particularly, the pyridazinone urea compounds of the present invention are .alpha.4.beta.7 integrin inhibitors useful for treating integrin mediated disorders.

L'invention concerne des composés de formule (I), des procédés de préparation associés, des compositions, des intermédiaires et des dérivés de ces composés. L'invention concerne également des méthodes de traitement des troubles induits par les intégrines .alpha.4. Plus particulièrement, les composés d'urées de pyridazinone selon l'invention sont des inhibiteurs des intégrines .alpha.4.beta.7, utiles dans le traitement des troubles induits par les intégrines.

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