Pyridazinones and furan-containing compounds

Details Pyridazinones and furan-containing compounds Pyridazinones and furan-containing compounds

C - Chemistry, Metallurgy

07

D

C07D 237/14 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 237/22 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2673299

The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

Cette invention se rapporte à des composés pyridazinone de formule (I) et à des composés furanniques de formule (II), à des compositions pharmaceutiques de composés de formule (I) et de formule (II), à des kits contenant ces composés, à des procédés de synthèse et à un procédé de traitement d'une maladie proliférative chez un sujet par administration d'une quantité thérapeutiquement efficace d'un composé de formule (I) ou de formule (II). Les deux classes de composés ont été identifiées par criblage d'un ensemble de bibliothèques de petites molécules.

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