C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/251
C07D 403/14 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1257588
Abstract This invention relates to compounds of general formula I Image (I) [wherein X represents an imino group optionally substituted by an alkyl or phenylalkyl group, or an oxygen or sulphur atom; R1 represents a saturated 5- to 7-membered alkyleneimino ring bonded via a nitrogen atom or a 5- to 7-membered saturated imino, N-alkylimino, N-phenylalkylimino, N-alkanoylimino or N-alkoxycarbonyliminoalkylene ring bonded via a carbon atom, whilst the above- mentioned rings may be substituted by one or two alkyl groups in the carbon structure and a methylene group in the 4-position of a 6- or 7-membered ring may be replaced by an oxygen or sulphur atom or by a sulphinyl, sulphonyl, imino, alkylimino, phenylalkyl- imino, alkoxycarbonylimino or alkanoylimino group; a saturated 5- to 7-membered alkyleneimino ring (optionally substituted by one or two alkyl groups) bonded via a nitrogen atom and in which a -CH2CH2- group is replaced by an -NH-CO- group, the -CO- group in this -NH-CO- group being linked to the first- mentioned N-atom; a 5-membered heteroaromatic ring bonded via a nitrogen atom, which may additionally contain an oxygen or sulphur atom, one or two nitrogen atoms, or an oxygen or sulphur atom and a nitrogen atom and in which the heteroaromatic ring may be substituted by one or two alkyl groups, or in the case of pyrazoles, may alternatively be substituted by a hydroxy and an alkyl group; a 5- or 6-membered heteroaromatic ring bonded via a carbon atom, in which the heteroaromatic ring may contain an oxygen or sulphur atom, one, two or three nitrogen atoms, or an oxygen or sulphur atom and one or two nitrogen atoms, whilst the heteroaromatic rings may be substituted by one or two alkyl groups, by an amino or alkanoylamino group or, in the case of pyridines, by one or two halogen atoms or by a halogen atom and an amino or morpholino group; and R2 represents a hydrogen atom or an alkyl group; whilst all the above-mentioned alkyl, alkanoyl or alkoxy groups may contain from 1 to 3 carbon atoms] and acid addition salts thereof. The compounds of general formula I above have interesting pharmacological properties, particularly antithrombotic and cardiovascular properties. The new compounds may be prepared using methods known per se.
505012
Bomhard Andreas
Diederen Willi
Hauel Norbert
Heider Joachim
Nan Meel Jacques
Fetherstonhaugh & Co.
Thomae (dr. Karl) Gesellschaft Mit Beschrankter Haftung
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