Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as...

Details Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as... Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/433 (2006.01) A61P 3/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2699718

Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

Cette invention concerne des composés de formule I où R2, R3, R13, L et D2 sont tels que définis dans la description, qui sont utilisés dans le traitement et/ou la prévention des maladies ou des affections associées avec des taux déficitaires de l'activité glucokinase, ou qui peuvent être traitées par activation de la glucokinase y compris, mais sans y être limités, le diabète sucré, l'intolérance au glucose, l'hyperglycémie modérée à jeun, la glycémie à jeun anormale, et toute autre maladie et affection comme celles évoquées ici.

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