C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/82 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 5/14 (2006.01) A61P 7/04 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 27/02 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A6
Patent
CA 2745004
To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): (see formula 1) or its salt or a solvate thereof.
L'invention porte sur un nouvel inhibiteur de JAK3 qui sutilise comme agent de prévention et/ou thérapeutique pour le rejet d'une greffe d'organe, la maladie du greffon contre l'hôte (GvHD), l'arthrite rhumatoïde, la sclérose en plaques, le lupus érythémateux disséminé, le syndrome de Sjogren, la maladie de Behçet, le diabète de type I, la thyroïdite auto-immune, le purpura thrombocytopénique idiopathique, la colite ulcérative, la maladie de Crohn, l'asthme, la conjonctivite allergique, la dermatite atopique, la dermatite de contact, l'urticaire, l'eczéma, le psoriasis, l'uvéite, le cancer, la leucémie, etc. L'invention porte sur un dérivé de pyridine-3-carboxyamide représenté par la formule générale (1) ou sur un sel de celui-ci ou un solvate de celui-ci.
Ashikawa Masanori
Doi Takeshi
Ishikawa Tetsuya
Ishiwata Hiroyuki
Kitamura Takahiro
Goudreau Gage Dubuc
Kowa Company Ltd.
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