Pyridine and pyrimidine derivatives as inhibitors of histone...

Details Pyridine and pyrimidine derivatives as inhibitors of histone... Pyridine and pyrimidine derivatives as inhibitors of histone...

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2633100

This invention comprises the novel compounds of formula (I), wherein R1, R2, R3, X, Y and Z have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Cette invention concerne de nouveaux composés de formule (I) dans laquelle R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, X, Y et Z ont les correspondances indiquées, ces composés ayant une activité enzymatique d'inhibition d'histone désacétylase ; leur préparation, des compositions les contenant, et leur utilisation en tant que médicament.

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