Pyridine and related aza heterocycle derivatives as...

Details Pyridine and related aza heterocycle derivatives as... Pyridine and related aza heterocycle derivatives as...

C - Chemistry, Metallurgy

07

D

167/225, 260/273

C07D 401/12 (2006.01) A61K 31/435 (2006.01) C07D 213/74 (2006.01) C07D 213/85 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2038317

31,191-00 PYRIDINE AND RELATED AZA HETEROCYCLE DERIVATIVES AS CARDIOVASCULAR AGENTS Abstract of the Disclosure Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: Image wherein R1 or R3 is a moiety of the formula: Image ; wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is - (CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrytbmia in mammals.

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