C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) A61P 35/00 (2006.01) C07D 241/12 (2006.01) C07D 241/20 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2673582
The present invention pertains generally to the field of therapeutic compounds,. arid more specifically to certain pyridine benzamide and pyrazine benzamide compounds (I) (referred to herein as PDBA and PZBA compounds) which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD1 that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.
La présente invention concerne en général le domaine des composés thérapeutiques, et plus spécifiquement certains composés benzamides de pyridine et benzamides de pyrazine (I) (désignés ici comme composés PDBA et PZBA) qui, entre autres, inhibent la protéine kinase D (PKD) (par exemple, la PKD1, la PKD2, la PKD3). La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et compositions, à la fois in vitro et in vivo, pour inhiber la PKD, et dans le traitement de maladies et conditions qui sont induites par la PKD1 qui sont améliorées par l'inhibition de la PKD, etc., y compris des conditions prolifératives telles que le cancer, etc.
Blackaby Wesley Peter
Charles Mark David
Ekwuru Chukuemeka Tennyson
Foxton Caroline Heather
Hammonds Timothy Robin
Cancer Research Technology Limited
Kirby Eades Gale Baker
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